Epigenetic Regulation of Tissue Resident Macrophage Ontogeny and Diversity

Tissue-resident macrophages are embryonically derived immune cells that serve to maintain homeostasis during pre- and post-natal life. Their ontogeny has been well mapped out, but the specific factors regulating their development remain enigmatic. Our group is actively working on defining the role of epigenetic proteins on the regulation of embryonic development of tissue-resident macrophages, their effect on macrophage function throughout life.

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Selected Publications

1. Yao Y, Liu Q, Adrianto I, et al. Histone deacetylase 3 controls lung alveolar macrophage development and homeostasis. Nat Commun. 2020;11(1):3822.
2. Yao Y, Martin C, Yin C, et al. Micro RNAs are required for Langerhans cell, skin- and lung-resident macrophage ontogeny. J Allergy Clin Immunol. 2018;142(3):976-978.e2.

3. Huang L, Li GH, Yu Q, et al. Smad2/4 signaling pathway is critical for epidermal langerhans cell repopulation under inflammatory condition but not required for their homeostasis at steady state. Front Immunol. 2020;11:912.