Spatial and Multi-Omics Profiling of Cutaneous Disease and Malignancy

Our Lab is leading efforts to better characterize cutaneous disease using spatially-resolved and single-cell multi-omics technology. Our efforts are centered around defining new features of cellular and molecular pathology in Hidradenitis Suppurativa, Psoriatic Arthritis, and Squamous Cell Carcinoma to better classify, treat, and prognosticate these diseases.​

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Selected Publications

1. Veenstra J, Ozog D, Loveless I, Adrianto I, Dimitrion P, Subedi K, Friedman B, Zhou L, Mi QS. Distinguishing keratoacanthoma from well-differentiated cutaneous squamous cell carcinona using single-cell spatial pathology. J Invest Dermatol. 2023 (in press). https://doi.org/10.1016/j.jid.2023.06.192

2. Dimitrion P, Hamzavi I, Yin C, Toor J, Subedi K, Khalasawi N, Miller A, Huggins R, Adrianto I, Veenstra J, Vellaichamy G, Hans A, Daveluy S, Athar M, Liao W, Lim H, Ozog D, Zhou L, Mi QS. Mass cytometry uncovers a distinct peripheral immune profile and upregulated CD38 expression in patients with hidradenitis suppurativa. Cellular & Molecular Immunology 2023; 20, 972-975.

3. Vellaichamy G, Dimitrion P, Zhou L, et al. Insights from γ-secretase: functional genetics of hidradenitis suppurativa. J Invest Dermatol. 2021;141(8):1888-1896.