Filaggrin Loss-of-Function Variants in Atopic Dermatitis

The de Guzman Strong lab discovered Filaggrin (FLG) loss-of-function (LOF) variants in African-American patients with moderate to severe atopic dermatitis (AD). We continue to investigate the genetics of AD in underserved populations using next-generation sequencing.

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Selected Publications

1. Mathyer ME, Quiggle AM, et al. Tiled array-based sequencing identifies enrichment of loss-of-function variants in the highly homologous filaggrin gene in African American children with severe atopic dermatitis. Exp Dermatology.2018 May 23;https://onlinelibrary.wiley.com/doi/10.1111/exd.13691

2. Quiggle AM, Goodwin ZA, et al. Low filaggrin monomer repeats in African-American pediatric patients with moderate to severe atopic dermatitis. JAMA Dermatology. 2015 May; 151(5): 557-59. https://jamanetwork.com/journals/jamadermatology/fullarticle/2089056